Synthesis of PLA-b-PEG Multiblock Copolymers for Stealth Drug Carrier Preparation

Synthesis of PLA-b-PEG multiblock copolymers for stealth drug carrier preparation.

An efficient method of preparing biodegradable and biocompatible multiblock copolymers from lactic acid and polyethylene glycol is proposed.

Biodegradable Multiblock Copolymers for Drug Delivery Applications

Microspheres of a hydrophobic and a hydrophilic poly(ether-ester) copolymer were evaluated for their in-vitro and in-vivo biocompatibility and degradation. The microspheres prior to and after sterilization were tested for in-vitro cytotoxicity. The invivo biocompatibility of the poly(ethylene glycol) terephthalate and poly(butylene terephthalate) (PEGT/PBT) microspheres was evaluated subcutaneo...

Effect of different mass ratio of PLA: PEG segments in PLA-PEG-PLA copolymers on the physicochemical characterization and DNA release profile

Background: Adapting controlled release technologies to the delivery of DNA has the great potential to overcome extracellular barriers that limit gene delivery. This study investigates the effect of different mass ratio of PLA: PEG in the various tri block poly (lactic acid)-poly (ethylene glycol) - Poly (lactic acid) copolymer (PLA-PEG-PLA) on the properties of the resulting nanoparticles. Me...

preparation and characterization of pla-peg-pla tri-block copolymer polymersomes as a novel carrier for lisinopril

Synthesis of polysaccharide-b-PEG block copolymers by oxime click.

The oxime click reaction is shown to be a straightforward methodology for the synthesis of poly(ethylene glycol) (PEG)-polysaccharide diblock copolymers. The method is applicable to unmodified polysaccharides with a reductive end as demonstrated for dextran, hyaluronic acid and chitosan. Notably the oxime click reaction is applied for the first time to the end modification of polysaccharides.